Louisiana has one of the highest maternal mortality rates in the country. And troublingly, Black women are dying from pregnancy-related deaths at over four times the rate of white women. According to a recent report, more than half of these deaths could have been prevented by making a system change, either at the patient, community, or hospital level. These findings illustrate the enormous potential that quality improvement initiatives have for reducing maternal mortality in Louisiana and eliminating the Black-white disparity in maternal deaths. Here, the Louisiana Perinatal Quality Collaborative shares seven opportunities for improvement.